ChemInform Abstract: cis- and trans-2,3,3a,4,5,9b-Hexahydro-1H-benz[e]indoles: Synthesis and Evaluation of Dopamine D2 and D3 Receptor Binding Affinity.

✍ Scribed by Xiaodong Song; A. Michael Crider; Sharon F. Cruse; Debasis Ghosh; Cheryl Klein-Stevens; Li Liang; Mark A. Scheideler; Annemarie Varming; Inger Soetofte

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 40 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199948134

✦ Synopsis

fused pyrrole derivatives fused pyrrole derivatives R 0160 3,3a,4,5,indoles: Synthesis and Evaluation of Dopamine D 2 and D 3 Receptor Binding Affinity.

-In order to find more D 3 receptor binding selective compounds different kinds of the title substances such as (X), (XI), and (XVIII) are synthesized. The structure-activity relationships are discussed. The structures of (VII), the (+)-enantiomer of (X), and the (-)-enantiomer of (XVIII) are determined by X-ray analysis. It is shown that the most active enantiomer has the 3aR absolute configuration. -(SONG, XIAODONG;