A microwave synthesis of the cis and trans isomers of 3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one: The influence of solvent and power output on the diastereoselectivity
✍ Scribed by Juan A. Vega; Sénida Cueto; Andrés Ramos; Juan J. Vaquero; JoséL. García-Navio; Julio Alvarez-Builla; Jesus Ezquerra
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 240 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A short and efficient protocol for the asymmetric synthesis of __cis__‐ and __trans__‐3,4‐dihydro‐2,4,8‐trihydroxynaphthalen‐1(2__H__)‐one (**1** and **2**, resp.) is described, with a phthalide annulation as the key step. Introduction of a OH substituent at position 2 was performed by
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