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Total Synthesis and Reassessment of the Phosphatase-Inhibitory Activity of the Antitumor Agent TMC-69-6H.

✍ Scribed by Alois Fuerstner; Fabian Feyen; Heino Prinz; Herbert Waldmann

Publisher
John Wiley and Sons
Year
2004
Weight
62 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monoca