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Total Synthesis and Reassessment of the Phosphatase-Inhibitory Activity of the Antitumor Agent TMC-69-6H

✍ Scribed by Alois Fürstner; Fabian Feyen; Heino Prinz; Herbert Waldmann

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
132 KB
Volume
115
Category
Article
ISSN
0044-8249

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## Abstract The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monoca