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Total Synthesis and Further Scrutiny of the in vitro Antifungal Activity of 6-Nonadecynoic Acid.

✍ Scribed by Nestor M. Carballeira; David Sanabria; Keykavous Parang


Publisher
John Wiley and Sons
Year
2006
Weight
9 KB
Volume
37
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES


Total Synthesis and Further Scrutiny of
✍ NΓ©stor M. Carballeira; David Sanabria; Keykavous Parang πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 74 KB πŸ‘ 2 views

## Abstract The antifungal, naturally occurring acetylenic fatty acid 6‐nonadecynoic acid was synthesized in three steps (18 % overall yield), for the first time starting with commercially available 1‐tetradecyne. The synthesis developed herein will facilitate the further study of the antifungal pr

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Mono and diesters of thiomalic acid with various alcohols were prepared, and the S-n-butyl derivatives of the diesters were prepared. These compounds were analyzed, various physical constants were determined, and the fungicidal and fungisfatic activities were measured, usin undecylenic acid as the s

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## Abstract __Herein we describe the scalable diastereoselective and enantioselective syntheses of eight enantiomers of hydroxy metabolites of saperconazole. The inβ€…vitro antifungal activity of the eight stereoisomers (compounds **1**–**8**) was compared against a broad panel of__ Candida__spp. (__