Synthesis and in vitro evaluation of the antifungal activity of a series of thiomalic acid derivatives

✍ Scribed by Woodrow R. Byrum; John E. Wintter; Jack T. Bryan

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 285 KB
• Volume: 53
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600530719

✦ Synopsis

Mono and diesters of thiomalic acid with various alcohols were prepared, and the S-n-butyl derivatives of the diesters were prepared. These compounds were analyzed, various physical constants were determined, and the fungicidal and fungisfatic activities were measured, usin undecylenic acid as the standard for comparlson against Tricbo ton men& mpfyter. Several of the compounds under the conditions o f z e tests e d i b i t e d fungicidal and/or fungistatic activity.

HIOMALIC ACID (mercaptosuccinic acid, 2-Tmercapto-l,4-butanedioic acid) possesses two structural features which are present in the structures of some commercially available antifungal compounds-namely, the -C-S-