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Total Synthesis Achieved Of N-Acetylneuraminic Acid

✍ Scribed by SELTZER, RICHARD J.


Book ID
127040150
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
285 KB
Volume
64
Category
Article
ISSN
0009-2347

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A new synthesis of N-acetylneuraminic ac
✍ RenΓ© Csuk; Martin Hugener; Andrea Vasella πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 German βš– 649 KB

A new synthesis of N-acetylneuraminic acid (NeuSAc; 28) via the aldehyde 10 is described. The aldehyde 10 was obtained from N-acetyl-o-glucosamine (11; 5 steps, overall yield ca. 6 %) or from o-glucono-1,s-lactone (17; 6 steps, overall yield ra. 57%). Thus, on the one hand, N-acetyl-D-mannosamine (1