A new synthesis of N-acetylneuraminic ac
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RenΓ© Csuk; Martin Hugener; Andrea Vasella
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Article
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1988
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John Wiley and Sons
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German
β 649 KB
A new synthesis of N-acetylneuraminic acid (NeuSAc; 28) via the aldehyde 10 is described. The aldehyde 10 was obtained from N-acetyl-o-glucosamine (11; 5 steps, overall yield ca. 6 %) or from o-glucono-1,s-lactone (17; 6 steps, overall yield ra. 57%). Thus, on the one hand, N-acetyl-D-mannosamine (1