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Synthesis of N-acetylneuraminic acid

✍ Scribed by H. Rinderknecht; T. Rebane


Book ID
112702451
Publisher
Springer
Year
1963
Tongue
English
Weight
219 KB
Volume
19
Category
Article
ISSN
1420-682X

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A new synthesis of N-acetylneuraminic ac
✍ RenΓ© Csuk; Martin Hugener; Andrea Vasella πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 German βš– 649 KB

A new synthesis of N-acetylneuraminic acid (NeuSAc; 28) via the aldehyde 10 is described. The aldehyde 10 was obtained from N-acetyl-o-glucosamine (11; 5 steps, overall yield ca. 6 %) or from o-glucono-1,s-lactone (17; 6 steps, overall yield ra. 57%). Thus, on the one hand, N-acetyl-D-mannosamine (1