Total Syntheses of Vancomycin
β Scribed by Alex J. Zhang; Kevin Burgess
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 96 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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Total Syntheses of Vancomycin and Eremomycin Aglycons. -Vancomycin aglycon (Ia) is obtained in 40 steps (longest linear sequence) from 3,5-dimethoxybenzyl alcohol (via amino acid 7). Eremomycin aglycon (Ib) is also successfully synthesized through an identical strategy. These syntheses provide dias
Vancomycin is a natural product with a complicated molecular architecture and clinical significance as an antibiotic for treatment of infections caused by gram positive bacteria. These two attributes have seduced several groups of organic chemists into attempting to prepare this molecule, but no suc