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Total Synthesis of Vancomycin

✍ Scribed by K. C. Nicolaou; Helen J. Mitchell; Nareshkumar F. Jain; Nicolas Winssinger; Robert Hughes; Toshikazu Bando


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
125 KB
Volume
38
Category
Article
ISSN
0044-8249

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o-Halosubstituted aromatic triazenes (e.g. I, Scheme 1) react with aryloxides (e.g. II, Scheme 1) in the presence of CuBr ´Me 2 S, K 2 CO 3 and pyridine in acetonitrile at reflux to afford biaryl ethers (e.g. V, Scheme 1). This general methodology (Tables and) was applied to the construction of the