Synthetic Studies Towards the Indole Alkaloid Tacamine. Part 4. Total Syntheses of Tacamine-Type Indole Alkaloids of Tabernaemontana eglandulosa. -Seven alkaloids (VI)-(VIII), (XII), and (XIV)-(XVI) are prepared via epimerization of the ester (II). However, attempted synthesis of the alkaloid (Β±)-19
Total syntheses of tacamine-type indole alkaloids of Tabernaemontana eglandulosa
β Scribed by David Din Belle; Arto Tolvanen; Mauri Lounasmaa
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 909 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
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## Abstract The synthesis of aldehyde intermediates suitable for the preparation of indole alkaloids of the tacamine (1) type is described. The four possible aldehydes 4β7 were prepared from methyl 5βethylnicotinate (8) in a few simple steps using a baseβcatalyzed epimerization as the final step (_
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