Total enantiospecific synthesis of 12(r)-hete
β Scribed by Ira M. Taffer; Robert E. Zipkin
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 116 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
All chemical yields refer to chromatographically homogeneous products. All new compounds exibited satisfactory spectral (IR, NMR, and mass ) data.
π SIMILAR VOLUMES
An expedient preparation of ll(R,S)-HETE which may be adapted to the synthesis of 11(S)-HETE is described. Corey and Kang' recently described the synthesis of 11(R)-HETE (s), which could serve as a precursor to the corresponding hydroperoxide 14 or peroxy-radical Is, substances implicated in prosta
The R-and S-isomers of 8-and 12-hydroxyeicosatetraenoic acid (8-and lP-HETE) were synthesized from dimethyl malate derived precursors.
New mono-and diaromatic analogues of the arachidonic acid metabolite 12-HETE have been prepared using versatile strategies. The easily accessible monoacetal of isophtalaldehyde 3 was developed as a key intermediate for these syntheses.