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Total chiral synthesis of azole antifungals via α-hydroxylation of ketones

✍ Scribed by Dinesh Gala; Donald J. DiBenedetto; Ingrid Mergelsberg; Max Kugelman; Schering-Plough Research


Book ID
103407953
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
239 KB
Volume
37
Category
Article
ISSN
0040-4039

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Enantioselective synthesis of protected
✍ Dieter Enders; Vidya Bhushan 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 282 KB

a-Benzyloxy aldehydes and a-acetoxy ketones 4 of high enantiomeric purity are prepared in good overall yields via oxaziridine mediated hydroxylation of chiral hydrazone azaenolates. As auxiliaries novel proline derived hydrazine reagents 5 are used. The importance of a-hydroxy carbonyl compounds as