Synthesis of chiral 1,2,3-triols via organocatalyzed α-hydroxylation of protected β-hydroxyaldehydes
✍ Scribed by Olivier Colin; Philippe Hermange; Christine Thomassigny; Christine Greck
- Book ID
- 113930427
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 797 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
a-Benzyloxy aldehydes and a-acetoxy ketones 4 of high enantiomeric purity are prepared in good overall yields via oxaziridine mediated hydroxylation of chiral hydrazone azaenolates. As auxiliaries novel proline derived hydrazine reagents 5 are used. The importance of a-hydroxy carbonyl compounds as
The synthesis of chiral, nonracemic, fully protected a,a-disubstituted a-amino acids via the Beckmann rearrangement of tosylated oximes 1 is described. The desired amino acids were obtained in good yields with excellent enantioseleetivities in relatively few steps.