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Asymmetric synthesis of α-alkylated cyclic ketones via chiral chelated lithioenamines

✍ Scribed by Shun-ichi Hashimoto; Kenji Koga


Book ID
104237108
Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
212 KB
Volume
19
Category
Article
ISSN
0040-4039

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Asymmetric synthesis of aldehydes via al
✍ Robert R. Fraser; Fuminori Akiyama; Jacques Banville 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 371 KB

The lithiation and alkylation of three aldehydes in the form of their a-phenethylimines has been shown to yield chiral a-alkvlaldehydes of 67-70% optical purity. We recently observed some unusual stereochemical preferences associated with lithiated ketimines (1) and aldimines (2). Both carbonyl deri