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Topoisomerase IIα Expression in Breast Cancer: Correlation with Outcome Variables

✍ Scribed by Depowski, Peter L.; Rosenthal, Seth I.; Brien, Thomas P.; Stylos, Scott; Johnson, Rebecca L.; Ross, Jeffrey S.

Book ID
109889719
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
512 KB
Volume
13
Category
Article
ISSN
0893-3952

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Topoisomerase II␣ (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs. TOP2A is amplified or deleted together with amplification of the closely located ERBB2/HER-2/neu oncogene in breast cancer. We characterized the copy number aberrations of TOP2A a