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Her-2/neuand Topoisomerase iiα in Breast Cancer

✍ Scribed by Tero A.H. Järvinen; Edison T. Liu


Book ID
110432422
Publisher
Springer US
Year
2003
Tongue
English
Weight
188 KB
Volume
78
Category
Article
ISSN
0167-6806

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Topoisomerase II␣ (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs. TOP2A is amplified or deleted together with amplification of the closely located ERBB2/HER-2/neu oncogene in breast cancer. We characterized the copy number aberrations of TOP2A a