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DNA topoisomerase IIα expression and the response toprimary chemotherapy in breast cancer

✍ Scribed by MacGrogan, G; Rudolph, P; Mascarel, I de; Mauriac, L; Durand, M; Avril, A; Dilhuydy, J M; Robert, J; Mathoulin-Pélissier, S; Picot, V


Book ID
109997707
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
154 KB
Volume
89
Category
Article
ISSN
0007-0920

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Topoisomerase II␣ (TOP2A) is a key enzyme in DNA replication and a molecular target for many important anticancer drugs. TOP2A is amplified or deleted together with amplification of the closely located ERBB2/HER-2/neu oncogene in breast cancer. We characterized the copy number aberrations of TOP2A a