DNA topoisomerase I and II in cancer chemotherapy: update and perspectives
β Scribed by Yves Pommier
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 690 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0344-5704
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The identification of human DNA topoisomerases as cellular targets for active anti-cancer drugs has stimulated further interest in topoisomerase function in tumour biology. Topoisomerase I and II catalytic activity is detectable in many normal and malignant tissues. However, little is known about th
## Abstract The essential trace element selenium is one of the most promising cancer chemopreventive agents. Data from preclinical studies have revealed that selenite, an inorganic form of selenium, may also be useful in cancer chemotherapy. DNA topoisomerases (topos) are the target of several usef