Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives

✍ Scribed by Francesco Epifano; Silvio Sosa; Aurelia Tubaro; M. Carla Marcotullio; Massimo Curini; Salvatore Genovese

• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 369 KB
• Volume: 21
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.11.107

✦ Synopsis

Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17,