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Syntheses, Characterization and Anti-inflammatory Activity of a Benzamide Derivative and its Metal Chelates

✍ Scribed by Govind Mohan; Rajesh Nagar

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
123 KB
Volume
11
Category
Article
ISSN
0268-2605

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✦ Synopsis

N-Phenylbenzamide-2,2Ј-dicarboxylic acid (PBDA) and its copper(II), nickel(II), cobalt (II), zinc(II) and manganese(II) chelates have been synthesized and characterized by their physical measurements, infrared and electronic spectra and magnetic moment data. In an acute anti-inflammatory test, the cobalt chelate was most active (31.1% inhibition) followed by the zinc and copper chelates, whereas the copper chelate (22.3% inhibition) was most active in an adjuvant arthritis test. Again the cobalt chelate was most active in the cotton-wad granuloma test. Gastric irritancy was markedly reduced after chelation by copper, followed in order by zinc, cobalt, manganese and nickel chelates.

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