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Toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with ulcerative colitis (UC)0

✍ Scribed by Pierik, Marie; Vermeire, Severine; El-Housni, Hakim; Claessens, Greet; Quertinmont, Eric; Joosens, Sofie; Van Gossum, Andre; Deviere, Jacques; Rutgeerts, Paul; Franchimont, Denis

Book ID: 122829314
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 186 KB
Volume: 124
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(03)81870-X

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## Abstract A nonsynonymous single nucleotide polymorphism (Asp299Gly) in the __Toll‐like receptor‐4__ (__TLR‐4__) gene affects the responsiveness to lipopolysaccharide in humans. To analyze this important polymorphism more efficiently, we developed a simple polymerase chain reaction (PCR) restrict