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Toll-like receptor 9 signaling can sensitize fibroblasts for apoptosis

✍ Scribed by Silke F. Fischer; Marc Rehm; Anette Bauer; Frederik Höfling; Susanne Kirschnek; Mark Rutz; Stefan Bauer; Hermann Wagner; Georg Häcker

Book ID
108152219
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
208 KB
Volume
97
Category
Article
ISSN
0165-2478

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## Location Matters Plasmacytoid dendritic cells (pDCs), an immune cell specialized to respond to viral infections, use Toll-like receptors (TLRs) 7 and 9 expressed in endosomes to sense viral nucleic acids. Triggering of TLR7 or 9 results in the induction of two distinct signaling pathways, one th