Nucleic acid structures are highly conserved through evolution and when self nucleic acids are aberrantly detected by toll-like receptors (TLRs) they contribute to autoimmune disease. For this reason, multiple regulatory mechanisms exist to prevent immune responses to self nucleic acids. TLR9 is a n
✦ LIBER ✦
Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling
✍ Scribed by Boyoun Park; Ludovico Buti; Sungwook Lee; Takashi Matsuwaki; Eric Spooner; Melanie M. Brinkmann; Masugi Nishihara; Hidde L. Ploegh
- Book ID
- 108152565
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 910 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1074-7613
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## Location Matters Plasmacytoid dendritic cells (pDCs), an immune cell specialized to respond to viral infections, use Toll-like receptors (TLRs) 7 and 9 expressed in endosomes to sense viral nucleic acids. Triggering of TLR7 or 9 results in the induction of two distinct signaling pathways, one th