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Tolerogenic dendritic cells impede priming of naïve CD8 + T cells and deplete memory CD8 + T cells

✍ Scribed by Kleijwegt, Fleur S.; Jansen, Diahann T. S. L.; Teeler, Josefine; Joosten, Antoinette M.; Laban, Sandra; Nikolic, Tatjana; Roep, Bart O.

Book ID
118758123
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
825 KB
Volume
43
Category
Article
ISSN
0014-2980

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Large number of T cells traffic through the liver. In order to examine the effects of such traffic on the phenotype of hepatocytes, we vaccinated mice using DNA vaccines encoding antigens with MHC class I-binding epitopes. Small numbers of activated CD8 ؉ T blasts (10 5 -10 6 / liver) changed the su