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Tolerogenic dendritic cells differentially modulate naïve and memory CD4+T cells

✍ Scribed by Amy E Anderson, Bethan Sayers, Julie Diboll, John D Isaacs…

Book ID
120706508
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
148 KB
Volume
9
Category
Article
ISSN
1478-6354

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Dendritic cells (DCs) secrete vesicles of endosomal origin, called exosomes, that bear major histocompatibility complex (MHC) and T cell costimulatory molecules. Here, we found that injection of antigen- or peptide-bearing exosomes induced antigen-specific naïve CD4+ T cell activation in vivo. In vi