Indirect activation of naïve CD4+ T cell
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Théry, Clotilde; Duban, Livine; Segura, Elodie; Véron, Philippe; Lantz, Olivier;
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Article
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2002
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Nature Publishing Group
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English
⚖ 381 KB
Dendritic cells (DCs) secrete vesicles of endosomal origin, called exosomes, that bear major histocompatibility complex (MHC) and T cell costimulatory molecules. Here, we found that injection of antigen- or peptide-bearing exosomes induced antigen-specific naïve CD4+ T cell activation in vivo. In vi