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Tolerance to the anticonvulsant effects of clobazam in mice

โœ Scribed by J.D. Wildin; Barbara J. Pleuvry


Book ID
118956523
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
850 KB
Volume
31
Category
Article
ISSN
0028-3908

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Monoamine turnover in the brain of mice
โœ H.-H Frey; S Jung; R Scherkl ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 689 KB

Mice were treated for 14 days with clonazepam, 0.5 mg/kg i.p. twice daily, during which time partial tolerance to the anticonvulsant effect against pentetrazole developed. The development of tolerance was paralleled by a reduced turnover of noradrenaline in the whole brain, and of dopamine in the mi