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Monoamine turnover in the brain of mice during development of tolerance to the anticonvulsant effect of clonazepam

✍ Scribed by H.-H Frey; S Jung; R Scherkl

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 689 KB
Volume: 8
Category: Article
ISSN: 0920-1211
DOI: 10.1016/0920-1211(91)90063-l

No coin nor oath required. For personal study only.

✦ Synopsis

Mice were treated for 14 days with clonazepam, 0.5 mg/kg i.p. twice daily, during which time partial tolerance to the anticonvulsant effect against pentetrazole developed. The development of tolerance was paralleled by a reduced turnover of noradrenaline in the whole brain, and of dopamine in the midbrain. The turnover of 5-HT was increased during the first week of treatment, but decreased thereafter. These changes in monoamine turnover, which are thought to be GABA-mediated, are consistent with an increased seizure susceptibility, and may contribute to the development of tolerance to the anticonvulsant effect of benzodiazepines.

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