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Tolerance to the anti-metastatic effect of lipopolysaccharide against liver metastasis in mice

✍ Scribed by Katsuaki Sato; Yung Choon Yoo; Kaori Matsuzawa; Ryosuke Watanabe; Ikuo Saiki; Shuichi Tono-Oka; Ichiro Azuma

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
780 KB
Volume
66
Category
Article
ISSN
0020-7136

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✦ Synopsis

We describe the involvement of endotoxin tolerance in the refractoriness of its anti-metastatic effect against murine syngeneic tumors. Three i.v. administrations of LPS at intervals of 4 days after tumor inoculation inhibited liver metastasis of L5 I78Y-ML25 cells, whereas 3 consecutive i.v. administrations of LPS showed only a slight suppressive effect. Multiple i.v. administrations of LPS, synthetic lipid A, its synthetic derivative DT-546 I, Staphylococcus aureus (S. oureus) BioParticles or Staphylococcal enterotoxin B (SEE) on days I, 5 and 9 after tumor inoculation inhibited liver metastasis of T-lymphoma cells in normal mice. The anti-metastatic effects of LPS, synthetic lipid A or DT-5461 but not S. aureus BioParticles or SEB were

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