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Tolerance to the Anticonvulsant Effect of Clorazepate and Clonazepam in Mice

โœ Scribed by Scherkl, R. ;Kurudi, Doxa ;Frey, H.-H.


Book ID
114801124
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
366 KB
Volume
62
Category
Article
ISSN
0901-9928

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๐Ÿ“œ SIMILAR VOLUMES


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Dogs were treated with clorazepate, which is known to be completely metabolized to desmethyldiazepam. 2 mgikg t.i.d. were given orally for 5-6 weeks, a dose regimen providing plasma concentrations of desmethyldiazepam in the range known to be therapeutic in man. The rate of development of tolerance

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Mice were treated for 14 days with clonazepam, 0.5 mg/kg i.p. twice daily, during which time partial tolerance to the anticonvulsant effect against pentetrazole developed. The development of tolerance was paralleled by a reduced turnover of noradrenaline in the whole brain, and of dopamine in the mi