𝔖 Bobbio Scriptorium
✦   LIBER   ✦

TmDOTA−: A Sensitive Probe for MR Thermometry in Vivo

✍ Scribed by Chun S. Zuo; Ashfaq Mahmood; A.Dean Sherry

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
107 KB
Volume
151
Category
Article
ISSN
1090-7807

No coin nor oath required. For personal study only.

✦ Synopsis

The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.

📜 SIMILAR VOLUMES

Improved calibration technique for in vi
Improved calibration technique for in vivo proton MRS thermometry for brain temperature measurement
✍ M. Zhu; A. Bashir; J.J. Ackerman; D.A. Yablonskiy 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 380 KB

## Abstract The most common MR‐based approach to noninvasively measure brain temperature relies on the linear relationship between the ^1^H MR resonance frequency of tissue water and the tissue's temperature. Herein we provide the most accurate in vivo assessment existing thus far of such a relatio

A new ytterbium chelate as contrast agen
A new ytterbium chelate as contrast agent in chemical shift imaging and temperature sensitive probe for MR spectroscopy
✍ Silvio Aime; Mauro Botta; Mauro Fasano; Enzo Terreno; Paul Kinchesh; Luisella Ca 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB

## Abstract A paramagnetic Yb(lll) complex that is the prototype of a novel class of probes for MRI and MRS has been developed. The complex displays highly shifted ^1^H resonances that are characterized by short relaxation times and, as such, may prove to be a valuable alternative in applications t

A Targeted Releasable Affinity Probe (TR
A Targeted Releasable Affinity Probe (TRAP) for In Vivo Photocrosslinking
✍ Ping Yan; Ting Wang; Gregory J. Newton; Tatyana V. Knyushko; Yijia Xiong; Diana 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 970 KB

## Abstract **A protein TRAP**: The in vivo photocrosslinking of TRAP after its intracellular targeting to a binding sequence on the bait protein stabilizes protein interactions. Because the crosslinker is releasable, simple mass spectrometry can be used to identify the protein binding sites after

Heteronuclear Cross Polarization for Enh
Heteronuclear Cross Polarization for Enhanced Sensitivity ofin Vivo13C MR Spectroscopy on a Clinical 1.5 T MR System
✍ Adrianus J. van den Bergh; Hendrikus J. van den Boogert; Arend Heerschap 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 318 KB

The potential of heteronuclear { 1 H-13 C} cross polarization was studied for optimization of the signal-to-noise ratio in in vivo 13 C MR spectroscopy at the clinical field strength of 1.5 T. Experiments on the human calf showed a significant chemical-shift selective signal enhancement on triglycer