Heteronuclear Cross Polarization for Enhanced Sensitivity ofin Vivo13C MR Spectroscopy on a Clinical 1.5 T MR System
✍ Scribed by Adrianus J. van den Bergh; Hendrikus J. van den Boogert; Arend Heerschap
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 318 KB
- Volume
- 135
- Category
- Article
- ISSN
- 1090-7807
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✦ Synopsis
The potential of heteronuclear { 1 H-13 C} cross polarization was studied for optimization of the signal-to-noise ratio in in vivo 13 C MR spectroscopy at the clinical field strength of 1.5 T. Experiments on the human calf showed a significant chemical-shift selective signal enhancement on triglyceride signals of 3.9 by heteronuclear cross polarization, compared to a standard pulseacquire sequence. Studies on a neonatal piglet brain showed an enhancement by cross polarization of 2.2 for the detection of 13 C-1-glucose. This enhancement allowed a fourfold improvement in time resolution in dynamic 13 C MR of 13 C-1-glucose inflow in piglet brain. Phantom experiments demonstrated the efficiency of this technique for interleaved detection of two spectral regions. Tests with a volume coil showed the feasibility of signal enhancement by cross polarization over a large volume of interest.