Titration of Barbiturates and Sulfa Drugs in Nonaqueous Solution*†
✍ Scribed by Vespe, Vincent ;Fritz, James S.
- Publisher
- Elsevier
- Year
- 1952
- Weight
- 262 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0095-9553
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📜 SIMILAR VOLUMES
The difference in pKa values for acetaminophen and the barbituric acids permits differentiation of mixtures containing these drugs. Ion-exchange chromatography is used t o separate acetaminophen and barbiturate from other active and inert constituents. Titrations are performed nonaqueously in dimeth
Therefore, it is concluded that the reaction between isoniazid and I1 under the experimental conditions of the assay method likely proceeds as depicted in Scheme 1. The present method can be modified to make it applicable to the determination of free isoniazid in biological fluids since none of the