Potentiometric titration of antithyroid drugs with mercuric acetate solution

✍ Scribed by Sergio Pinzauti; Vittorio Dal Piaz; Enzo La Porta

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 331 KB
• Volume: 62
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600620631

✦ Synopsis

Therefore, it is concluded that the reaction between isoniazid and I1 under the experimental conditions of the assay method likely proceeds as depicted in Scheme 1.

The present method can be modified to make it applicable to the determination of free isoniazid in biological fluids since none of the most important metabolites of isoniazid that have been identified (acetylisoniazid, isonicotinic acid, isonicotinylglycine, pyruvic acid isonicotinylhydrazine, and a-oxoglutaric acid isonicotinylhydrazine) (12) possesses a free amino function in the molecule. Further studies are in progress, and the results will be reported at a later date.