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Analysis of acetaminophen and barbiturate combinations by differentiating nonaqueous titration

โœ Scribed by Martin I. Blake; James Hunt; Harold J. Rhodes

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
328 KB
Volume
63
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The difference in pKa values for acetaminophen and the barbituric acids permits differentiation of mixtures containing these drugs. Ion-exchange chromatography is used t o separate acetaminophen and barbiturate from other active and inert constituents. Titrations are performed nonaqueously in dimethylformamide using tetrabutylammonium hydroxide as the titrant and a titrimeter equipped with a calomel and platinum electrode system.

Keyphrases Acetaminophen-barbiturate in combination-analysis by differentiating nonaqueous titration 0 Barbiturate-acetaminophen in combination-analysis by differentiating nonaqueous titration 0 Titrimetry, differentiating nonaqueous-analysis of acetaminophen-barbiturate in combination

๐Ÿ“œ SIMILAR VOLUMES

Analysis of Barbiturate Salts in Various
Analysis of Barbiturate Salts in Various Dosage Forms by an Ion Exchange and Nonaqueous Titration Procedure**School of Pharmacy, North Dakota Agricultural College, Fargo
โœ Vincent, Muriel C. ;Blake, Martin I. ๐Ÿ“‚ Article ๐Ÿ“… 1959 ๐Ÿ› Elsevier โš– 199 KB ๐Ÿ‘ 1 views

Barbiturate salts in various dosage forms are determined by liberating the barbituric acid from the salt by passage through a cation exchange resin. Dimethylformamide is used as the solvent. The barbituric acid is titrated visually with 0.1 N sodium methoxide in benzene-methanol. The method is rapid