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Titelbild: Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic Alkylation of Ketones: Me2Zn Addition to α-Ketoesters (Angew. Chem. 44/2003)

✍ Scribed by Ken Funabashi; Markus Jachmann; Motomu Kanai; Masakatsu Shibasaki

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
25 KB
Volume
115
Category
Article
ISSN
0044-8249

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Multicenter Strategy for the Development
Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic Alkylation of Ketones: Me2Zn Addition to α-Ketoesters
✍ Ken Funabashi; Markus Jachmann; Motomu Kanai; Masakatsu Shibasaki 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 2 views

The catalytic construction of stereogenic tetrasubstituted carbon centers through the addition of carbon nucleophiles to ketones or ketoimines is very challenging, partly because of the lower reactivity of these substrates relative to aldehydes and aldoimines. [1] This task requires strong activatio