The catalytic construction of stereogenic tetrasubstituted carbon centers through the addition of carbon nucleophiles to ketones or ketoimines is very challenging, partly because of the lower reactivity of these substrates relative to aldehydes and aldoimines. [1] This task requires strong activatio
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Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic Alkylation of Ketones: Me2Zn Addition to α-Ketoesters
✍ Scribed by Ken Funabashi; Markus Jachmann; Motomu Kanai; Masakatsu Shibasaki
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 142 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0044-8249
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