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Tissue-Specific Involvement of Multiple Mitochondrial DNA Deletions in Familial Mitochondrial Myopathy

✍ Scribed by Satoshi Nishizuka; Gen Tamura; Yu-ichi Goto; Kumiko Murayama; Toshiaki Konno; Mika Hakozaki; Ikuya Nonaka; Hideo Tohgi; Ryoichi Satodate


Book ID
115582153
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
113 KB
Volume
247
Category
Article
ISSN
0006-291X

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## Abstract By using a combination of Southern blot hybridization analysis, polymerase–chain reaction amplification, and direct nucleotide sequencing, we studied deletions of mitochondrial DNA (mtDNA) in several nonfamilial patients with progressive external ophthalmoplegia and Kearns‐Sayre syndrom