## Abstract By using a combination of Southern blot hybridization analysis, polymeraseβchain reaction amplification, and direct nucleotide sequencing, we studied deletions of mitochondrial DNA (mtDNA) in several nonfamilial patients with progressive external ophthalmoplegia and KearnsβSayre syndrom
Widespread tissue distribution of multiple mitochondrial DNA deletions in familial mitochondrial myopathy
β Scribed by Dr. Shingo Kawashima; Dr. Shigeo Ohta; Dr. Yasuo Kagawa; Dr. Mitsuo Yoshida; Dr. Masatoyo Nishizawa
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 584 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0148-639X
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Inclusion body myositis (IBM) is a sporadic progressive myopathy, which is morphologically characterized by inflammatory cell infiltrates and rimmed vacuoles in muscle fibers. Mitochondrial changes are regularly present with ragged-red fibers showing deficiency of cytochrome c oxidase. In these musc
## Abstract Inclusion body myositis, a chronic inflammatory disorder, is the most common cause of myopathy in adults over the age of 50. Diagnosis is based on clinical features and distinctive morphological findings by both light and electron microscopy. The causes of inclusion body myositis are st