Multiple mitochondrial DNA deletions in hereditary inclusion body myopathy
✍ Scribed by Monica Jansson; Niklas Darin; Mårten Kyllerman; Tommy Martinsson; Jan Wahlström; A. Oldfors
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 477 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0001-6322
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Inclusion body myositis (IBM) is a sporadic progressive myopathy, which is morphologically characterized by inflammatory cell infiltrates and rimmed vacuoles in muscle fibers. Mitochondrial changes are regularly present with ragged-red fibers showing deficiency of cytochrome c oxidase. In these musc
## Abstract Inclusion body myositis, a chronic inflammatory disorder, is the most common cause of myopathy in adults over the age of 50. Diagnosis is based on clinical features and distinctive morphological findings by both light and electron microscopy. The causes of inclusion body myositis are st