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Tissue response to implanted polymers: The significance of sample shape

✍ Scribed by Matlaga, Barbara F. ;Yasenchak, Lewis P. ;Salthouse, Thomas N.

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
366 KB
Volume
10
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

Studies were designed to demonstrate the need for standardization of shape of samples used as implants to evaluate histotoxicity of polymer materials. Six medical‐grade polymers (polypropylene, polyethylene, polyurethane, silicone rubber, poly(vinyl chloride), and Teflon) were extruded as rods with circular‐, triangular‐, and pentagonal‐shaped crosss ections, and were implanted in rat gluteal muscles for 14 days. Evaluation of the tissue response was assessed by quantitating cellular lysosomal acid phosphatase enzyme activity by using microspectrophotometry. All triangular‐shaped implants showed the highest enzyme activity and cellular response; pentagon shapes showed less, and circular rods showed the lowest activity. The results demonstrate the need for standard sample shape for valid comparative studies of tissue response to implanted polymers.

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