In vivo time course studies of the tissue responses to resorbable polylactic acid implants by means of MRI
✍ Scribed by Patrick W. Stroman; Jean-Claude Dorvil; Yves Marois; Nicolas Poddevin; Robert Guidoin
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 164 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Magnetic resonance (MR) imaging and relaxation time measurements of bioresorbable implants made of polylactic acid (PLA), as well as the surrounding tissues, were carried out over a period of 6 months to monitor the implant state and the body's responses, and to determine how these processes are reflected in MR data. Twelve rabbits each received two subcutaneous PLA implants (45 ؋ 10 ؋ 2 mm). Changes in tissue relaxation rates demonstrated inflammation and tissue healing time courses but were not simply linear functions of the tissue water content and so provide new insight into MR characterization of inflammatory processes. Magn Reson Med 42:210