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Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine: Lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at O-6 of guanine

✍ Scribed by J.V. Frei; P.D. Lawley


Book ID
113135619
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
585 KB
Volume
13
Category
Article
ISSN
0009-2797

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Kinetics of induction of DNA damage and
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␤-Propiolactone (BPL) and N-methyl-NЈ-nitro-N-nitrosoguanidine (MNNG) are two direct alkylating agents that induce multiple genetic lesions and tumors in the rodent stomach. We measured the kinetics of the induction of DNA damage by using the single-cell gel electrophoresis assay (SCGE) and the indu