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P1A2 - Use of single cell gel electrophoresis assay for the detection of tissue-specific DNA damage in mouse gastric mucosa after acute oral administration of N-methyl-N′-nitro-nitrosoguanidine and β-propiolactone

✍ Scribed by D. Brault; D. Renault; V. Thybaud

Book ID: 119539889
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 122 KB
Volume: 95
Category: Article
ISSN: 0378-4274
DOI: 10.1016/s0378-4274(98)80143-4

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␤-Propiolactone (BPL) and N-methyl-NЈ-nitro-N-nitrosoguanidine (MNNG) are two direct alkylating agents that induce multiple genetic lesions and tumors in the rodent stomach. We measured the kinetics of the induction of DNA damage by using the single-cell gel electrophoresis assay (SCGE) and the indu