Tin-directed nazarov cyclizations: A versatile route to cyclopentenoids
โ Scribed by Michael R. Peel; Carl R. Johnson
- Book ID
- 104219447
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 214 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
The preparation of 1 -(trt-butylstannyl)-1 ,Cpentadien9-ones and their efficient Nazarov cyclizations to cyclopentenones, including a PGA analogue, are described.
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## Abstract An efficient synthetic protocol for the preparation of4โ[(methoxycarbonyl)methyl]โ3,4โdihydroisoquinolinโ1โonesfrom __N__โallylamides of 2โiodobenzoic acids has been performed under 100 atm of carbon monoxide. Pyridine ring formation occurs through an intramolecular Pdโcatalyzed carbonโ