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Palladium-Catalyzed Cyclization/Carbonylation as a Direct Route to 4-[(Methoxycarbonyl)methyl]-3,4-dihydroisoquinolinones

✍ Scribed by G. Attilio Ardizzoia; Egle M. Beccalli; Elena Borsini; Stefano Brenna; Gianluigi Broggini; Micol Rigamonti

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 194 KB
Volume: 2008
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200800747

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✦ Synopsis

Abstract

An efficient synthetic protocol for the preparation of4‐[(methoxycarbonyl)methyl]‐3,4‐dihydroisoquinolin‐1‐onesfrom N‐allylamides of 2‐iodobenzoic acids has been performed under 100 atm of carbon monoxide. Pyridine ring formation occurs through an intramolecular Pd‐catalyzed carbon–carbon bond formation, followed by an alkoxycarbonylation process.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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ChemInform Abstract: Palladium-Catalyzed

ChemInform Abstract: Palladium-Catalyzed Cyclization/Carbonylation as a Direct Route to 4-[(Methoxycarbonyl)methyl]-3,4-dihydroisoquinolinones (IV), (VI).

✍ G. Attilio Ardizzoia; Egle M. Beccalli; Elena Borsini; Stefano Brenna; Gianluigi 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

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