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Time-resolved absorption spectroscopy of hematoporphyrin and its photoproducts

✍ Scribed by R. Rotomskis; V. Vaičaitis; A. Piskarskas

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
313 KB
Volume
202
Category
Article
ISSN
0009-2614

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✦ Synopsis

Irradiation of an aqueous solution of hematoporphyrin causes the formation of the stable photoproduct which may play an important role in cancer therapy. The spectra and kinetic characteristics of the absorption changes of hematoporphyrins and their photoproducts were measured by a picosecond pump and probe absorption spectrophotometer with continuous tunability of pump and probe pulses in the spectral region of 400-1500 nm with an accuracy better than 1 O-' optical units and with a temporal resolution less than 10 ps. Careful examination of the differential absorption spectra showed that the photoproduct is involved in aggregates or exists as a part of the covalently linked oligomer of hematoporphyrins.

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