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Time-dependent effects of fatty acids on skeletal muscle metabolism

✍ Scribed by Sandro M. Hirabara; Leornardo R. Silveira; Fernando Abdulkader; Carla R.O. Carvalho; Joaquim Procopio; Rui Curi

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
342 KB
Volume
210
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Increased plasma levels of free fatty acids (FFA) occur in states of insulin resistance such as type 2 diabetes mellitus, obesity, and metabolic syndrome. These high levels of plasma FFA seem to play an important role for the development of insulin resistance but the mechanisms involved are not known. We demonstrated that acute exposure to FFA (1 h) in rat incubated skeletal muscle leads to an increase in the insulin‐stimulated glycogen synthesis and glucose oxidation. In conditions of prolonged exposure to FFA, however, the insulin‐stimulated glucose uptake and metabolism is impaired in skeletal muscle. In this review, we discuss the differences between the effects of acute and prolonged exposure to FFA on skeletal muscle glucose metabolism and the possible mechanisms involved in the FFA‐induced insulin resistance. J. Cell. Physiol. 210: 7–15, 2007. © 2006 Wiley‐Liss, Inc.

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