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Effect of lactulose on the metabolism of short-chain fatty acids

โœ Scribed by Misael Uribe; Octavio Campollo; Christiane Cote

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
273 KB
Volume
12
Category
Article
ISSN
0270-9139

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โœฆ Synopsis

Short-chain (C,-C,) fatty acids account for 80%-70%

of the anions in the colon. Acetate (C,) is nontoxic in contrast to C,,,,-C, fatty acids (propionate, butyrate, isobutyrate, valerate, and isovalerate). which induce coma in animals and may be important in the patho-gen& of hepatic coma in humans. A n in-vitro fecal incubation eystem was used to map out short-chain fatty acid production in the presence of lactuloee, amino acids, albumin, or blood. Albumin and blood increased production of all C,-C, fatty acids. In contrast, lactulose waa converted to acetate only and increased fecal acidity. The degradation of amino acids, albumin, and blood to short-chain fatty acids was

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